Motor neuropathy-Motor neuron syndromes

Overview

Multifocal motor neuropathy (MMN) Anti-GM1 antibodies: Indications Only use laboratories that find IgM anti-GM1 antibodies in > 40% of patients with MMN < 2% of patients with ALS M-protein Immunofixation methodology should be used. Check in serum & urine. Serum protein electrophoresis and immunoelectrophoresis are not sensitive enough to detect many M-proteins Also measure quantitative immunoglobulins Anatomical evaluation of spine & posterior fossa Electrodiagnostic testing Rule out: Focal nerve lesion(s); Conduction block Neuropathy vs. Myopathy Genetic testing: Usually with symmetric weakne

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