Multifocal Motor Neuropathy (MMN) & Immune Motor Neuropathies (IMN) 3,14

Overview

Antibodies Clinical Electrodiagnostic Epidemiology Laboratory Pathology Treatment Variants & DDx MMN: Focal weakness Finger extension: Involvement varied MMN: Median nerve conduction block Thenar eminence: Weakness No atrophy early in disease Epidemiology Male > Female: 2-3 to 1 Prevalence: 0.29 to 1 per 100,000 (~ 5% to 10% of ALS prevalence) Drug treatment association: TNF-α antagonists, anecdotal reports Possible associated immune disorders: Ankylosing spondylitis, Crohn's disease, Celiac disease Genetics Higher frequency of homozygous SMN2 deletion (40%) than controls (10%) 17 HLA-DRB1-15:

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