Guillain-Barré-like syndrome with serum IgM binding to GalNAc-GD1a ganglioside

Immune/Antibody

antibody/gbs.htm#Guillain-Barré-like syndrome with serum IgM binding to GalNA

Overview

From WUSTL Neuromuscular

Epidemiology Japanese patients Younger onset: Mean 3rd decade ? Female > Male Clinical Prodrome GI: Campylobacter jejuni (75%) Respiratory: Cytomegalovirus Weakness: Mild; Proximal + Distal Sensory: Paresthesias ± Loss (75%); More common with CMV prodrome Cranial nerves: Facial weakness (27% to 80%); More common with CMV prodrome Recovery: Good at 1 month; Better than with IgG or no antibodies Electrodiagnostic Demyelination in many (38% to 64%) Axonal loss uncommon Serum antibody IgM vs GalNAc-GD1a ganglioside Cross reactive with GM2 ganglioside: 100% with CMV prodrome; 50% with GI prodrome P