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Features of motor syndromes: Likely response to therapy

Immune/Antibody

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Overview

From WUSTL Neuromuscular

Clinical Pattern of Weakness MotorConduction Block Other Evidenceof Demyelination Serum IgM vsGM1 Ganglioside or NS-6S Therapy Evidence forRx Efficacy Distal Asymmetric + + or - + Cyclophosphamide Immune GlobulinRituximab Not Prednisone Strong Distal Asymmetric - - + CyclophosphamideRituximab Moderate Distal Asymmetric + + or - - CyclophosphamideIVIg Moderater/o CIDP Distal Asymmetric - + + or - Cyclophosphamide? IVIg Moderate Distal Asymmetric - - - ? None Proximal - - - ? None UMN Signs + or - + or - + or - ? None Cyclophosphamide Treatment ProtocolCyclophosphamide for Myasthenia GravisMotor

Related Conditions

Shared genes

Acute Motor (Axonal) Neuropathy (AMAN)

Antibodies vs Glycolipids & Glycoproteins

C. Anti-GM1 Antibodies

Chronic Immune Demyelinating Neuropathies: Variants

Guillain-Barré-like syndrome with serum IgM binding to GalNAc-GD1a ganglioside

GD1AGM1PATHOLOGY

Lower Motor Neuron Syndrome: Proximal Arm Predominant 1,

Motor neuropathy-Motor neuron syndromes

Multifocal Motor Neuropathy (MMN) & Immune Motor Neuropathies (IMN) 3,14

External Resources

WUSTL Neuromuscular

Washington University Disease Center

Biomedical Literature

NCBI Expert-Authored Reviews

Portal for Rare Diseases

National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.