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Antibodies vs Glycolipids & Glycoproteins

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Overview

From WUSTL Neuromuscular

Anti-GM1 antibodies: Motor syndromes IgM vs GM1 Motor: Asymmetric, Distal, Chronic Demyelinating or Axonal IgG vs GM1 Signs: Motor predominant; Occasional sensory loss also Syndromes Acute: Symmetric, with Campylobacter jejuni infection, or Chronic: Asymmetic, Distal, without conduction block. Polyneuropathy with anti-MAG antibodies Sensory > Motor, Symmetric, Distal > Proximal May also have gait ataxia or tremor Demyelination with prolonged distal latencies But only rarely conduction block. Polyneuropathy with anti-Sulfatide antibodies Signs: Sensory loss Syndromes M-protein (IgM): GALOP synd

Related Conditions

Shared genes
"Classic" Guillain-Barré Syndrome
H131GD1A
Acute Immune Polyneuropathies
GD1APATHOLOGY
Acute Motor (Axonal) Neuropathy (AMAN)
IIGQ1BGM1
ACUTE NEUROPATHIES
GD1A
Axonal Sensory Neuropathies with Serum IgM binding to Trisulfated Heparin Disaccharide (TS-HDS)
HDSDISACCHARIDEMAG
C. Anti-GM1 Antibodies
GM1IGMGM1LMN
Chronic Immune Demyelinating Neuropathies: Variants
GD1AMOTORGM1
Classification of Acute Immune Neuropathies
GD1A

External Resources

WUSTL Neuromuscular
Washington University Disease Center
PubMed
Biomedical Literature
GeneReviews
NCBI Expert-Authored Reviews
Orphanet
Portal for Rare Diseases
NORD
National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.