Neuropathies (Chronic) with IgM binding to GD1a, GM3 & GT1b gangliosides
VariableImmune/Antibody
W
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antibody/pnimdem.html#Neuropathies (Chronic) with IgM binding to GD1a, GM3 & GT1b
Overview
From WUSTL NeuromuscularMotor-Sensory Neuropathy 11 Onset 7th decade Weakness & Numbness Clinical Sensory loss: Symmetric; Distal; Especially temperature Weakness: Mild; Distal > Proximal; Symmetric Tendon reflexes: Reduced Course: Slowly progressive over years Laboratory Electrodiagnostic testing: Demyelinating neuropathy Distal latencies: Prolonged Nerve conduction velocities: Slow; Variable F-waves: Absent Serum M-protein: None detected; IgM antibodies all κ type Serum IgM binding: Anti-GD1a antibodies GD1a ganglioside: Neu5Acα2-3Galβ- moiety Cross-reactivity: GT1b & GM3 gangliosides Motor Neuropathy 12 Onset 8th
Related Conditions
Shared genes"Classic" Guillain-Barré Syndrome
H131GD1A
Acute Immune Polyneuropathies
GD1APATHOLOGY
Acute Motor (Axonal) Neuropathy (AMAN)
IIGQ1BGM1
ACUTE NEUROPATHIES
GD1A
Antibodies vs Glycolipids & Glycoproteins
GM1MAGGQ1B
Chronic Immune Demyelinating Neuropathies: Variants
GD1AMOTORGM1
Classification of Acute Immune Neuropathies
GD1A
Demyelinating ataxic neuropathy with IgM binding to GalNAc-GD1a and GM2 gangliosides
GD1AACUTECHRONIC
External Resources
Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.