Monoclonal Gammopathies of Unknown Significance (& Other)
Immune/Antibody
W
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antibody/mprotein.htm#Monoclonal Gammopathies of Unknown Significance (& Other)
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Overview
From WUSTL NeuromuscularGeneral characteristics of M-proteins Types of light chain: κ > λ Quantity: < 3 g/dl Urine monoclonal: Rare Marrow plasma cells: < 5% Skeletal lesions (X-ray): Absent CBC: Normal Organomegaly: None Clonal cells: CD38+, CD56+, CD19- Immunoglobulin (Ig) heavy chain class Patient group (%) IgG IgM IgA IgD Biclonal Light chain All M-proteins 70 15 12 < 1 3 3 Polyneuropathy & MGUS 35 50 12 3 Testing 18 Detection of M-protein: Serum & Urine Neurology: Test with most sensitive method Sensitive clinical methods: Immunofixation 2/Immunotyping After M-protein found CBC with smear Chemistry panel with Ca
Related Conditions
Shared genes"Classic" Guillain-Barré Syndrome
H131GD1A
Acute Immune Polyneuropathies
GD1APATHOLOGY
Acute Motor (Axonal) Neuropathy (AMAN)
IIGQ1BGM1
ACUTE NEUROPATHIES
GD1A
Antibodies vs Glycolipids & Glycoproteins
GM1MAGGQ1B
Axonal Sensory Neuropathies with Serum IgM binding to Trisulfated Heparin Disaccharide (TS-HDS)
HDSDISACCHARIDEMAG
Chronic Immune Demyelinating Neuropathies: Variants
GD1AMOTORGM1
CHRONIC IMMUNE POLYNEUROPATHIES: AXONAL
HDS
External Resources
Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.