Myelin Glycoproteins
Laboratory / Diagnostics
W
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Overview
From WUSTL NeuromuscularGlycoproteinProperties P0 Location: Compact PNS myelin; Promyelinating Schwann cells; Büngner bands Abundant: 50% of PNS myelin proteins Molecular: Contains sulfated N-glycans; 30-kDa Function: Stabilizes intraperiod line of compact PNS myelin by homophilic interactions Diseases: CMT 1B; Dejerine-Sottas (CMT III); Congenital Hypomyelinating neuropathy Myelin associated glycoprotein Locations CNS > PNS Cells: Myelin-forming oligodendrocytes & Schwann cells Membranes: Periaxonal Schwann cell; ? Abaxonal Molecular: 100 kDa N-linked glycosylation: 30% by weight; Contain sialic acid, sulfate & GlcN
Related Conditions
Shared genesAntibodies vs Glycolipids & Glycoproteins
GM1MAGGQ1B
Axonal Sensory Neuropathies with Serum IgM binding to Trisulfated Heparin Disaccharide (TS-HDS)
HDSDISACCHARIDEMAG
I. Clinical Indications for Measurement of anti-MAG antibodies
MAG
II. Results with Specificity and Sensitivity for Sensory-Motor Neuropathies
MAG
III. Testing Laboratory Standards for anti-MAG Antibodies.
MAG
IV. Interpretations of Confirmed Positive anti-MAG Results
MAG
IV. Positive Result: Clinical Utility and Interpretations
MAG
Monoclonal Gammopathies of Unknown Significance (& Other)
MAGGD1AHDS
External Resources
Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.