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II. Results with Specificity and Sensitivity for Sensory-Motor Neuropathies

Immune/Antibody

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Overview

From WUSTL Neuromuscular

ELISA results IgM vs specially purified MAG (Z-MAG) > 1,500 Low IgM vs Histone H3 Western blot analysis: Necessary to confirm IgM binding to MAG. Associations of titers of IgM binding to MAG > 6,000: 90% specificity for demyelinating polyneuropathy. 1,500 to 6,000: Less association with demyelination.

Related Conditions

Shared genes

Antibodies vs Glycolipids & Glycoproteins

Axonal Sensory Neuropathies with Serum IgM binding to Trisulfated Heparin Disaccharide (TS-HDS)

HDSDISACCHARIDEMAG

I. Clinical Indications for Measurement of anti-MAG antibodies

III. Testing Laboratory Standards for anti-MAG Antibodies.

IV. Interpretations of Confirmed Positive anti-MAG Results

IV. Positive Result: Clinical Utility and Interpretations

Monoclonal Gammopathies of Unknown Significance (& Other)

Myelin Glycoproteins

External Resources

WUSTL Neuromuscular

Washington University Disease Center

Biomedical Literature

NCBI Expert-Authored Reviews

Portal for Rare Diseases

National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.