Myelin-Associated Glycoprotein (MAG; siglec-4) 1,4
Laboratory / DiagnosticsOMIM 600751
W
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lab/schcell.html#Myelin-Associated Glycoprotein (MAG; siglec-4)
1,4
Overview
From WUSTL NeuromuscularCharacteristics of MAG protein Myelin glycoprotein Abundance in myelin: CNS 1%; PNS 0.1% Family: siglec proteins Sialic acid binding Bind glycoconjugate ligands in sialic acid-dependent manner α2,3-linked sialic acid Also interact at least with three terminal monosaccharide units Function similar to selectins Immunoglobulin superfamily Extracellular IgG domains: Amino terminal V-set, followed by C2-set Most have functional roles in immune or nervous system Other siglec family members Sialoadhesin (siglec-1) CD22 (siglec-2) CD33 (siglec-3) siglec-5 siglec-6 2 Isoforms S-MAG 67kD after deglycosy
OMIM Entries
Related Conditions
Shared genesAntibodies vs Glycolipids & Glycoproteins
GM1MAGGQ1B
Axonal Sensory Neuropathies with Serum IgM binding to Trisulfated Heparin Disaccharide (TS-HDS)
HDSDISACCHARIDEMAG
I. Clinical Indications for Measurement of anti-MAG antibodies
MAG
II. Results with Specificity and Sensitivity for Sensory-Motor Neuropathies
MAG
III. Testing Laboratory Standards for anti-MAG Antibodies.
MAG
IV. Interpretations of Confirmed Positive anti-MAG Results
MAG
IV. Positive Result: Clinical Utility and Interpretations
MAG
Monoclonal Gammopathies of Unknown Significance (& Other)
MAGGD1AHDS
External Resources
Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.