Isaac's Syndrome

Overview

Associated disorders Clinical Differential diagnosis EMG Laboratory Clinical Features Onset age Range: 9 to 80 years Most < 60 years Mean 46 years Symptoms fluctuate In severity over periods of months Precipitated by exercise or muscle contraction Movements Often visible Types Myokymia Neuromyotonia Fasciculations Muscle twitching: Symptomatic in 12% to 40% Cramps & Stiffness Stiffness at rest May be induced or exacerbated by exercise Distribution Distal > Proximal Face, tongue & Pharyngeal muscles may be involved Intermittent Delayed muscle relaxation No percussion induced contraction Muscle

OMIM Entries

Related Conditions

External Resources