Inclusion Body Myositis (IBM)
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antibody/infmyop.htm#Inclusion Body Myositis (IBM)
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Overview
From WUSTL NeuromuscularNosology: Pathology groups Inflammatory Myopathy with Vacuoles, Aggregates & Mitochondrial Pathology (IM-VAMP) Inflammatory myopathy + Mitochondrial pathology Epidemiology 94 Sporadic: No family history Males Preponderance: 57% to 75% Later onset Frequency (Prevalence) General populations: 1 to 10/106 > 50 years of age: 139/106 Norway: 33/106 Turkey: 1/106 HIV 103 IM-VAMP is most common associated inflammatory myopathy May present with Onset age: 10 years younger than other IBM Proximal weakness Serum CK high NT5C1A antibodies (64%) HTLV Sarcoid & Granulomatous myopathies May have association
OMIM Entries
Related Conditions
Shared genesAsymmetric Myopathic Weakness
VAMP
CMT IA
PMP-22GENETM
Finger Flexion Weakness
VAMP
Granulomatous Myopathies
VAMP
Immune & Inflammatory Myopathies: Neoplasm Associations
VPVAMP
Inflammatory & Immune Myopathies (IIM): Acquired
RNAVAMPINCLUSION
Inflammatory Myopathy + Mitochondrial Pathology in muscle (IM-Mito), subtype of IM-VAMP
VAMP
Isaac's Syndrome
ACHRRIADRB1
External Resources
Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.