Muscle Membrane Proteins
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Overview
From WUSTL NeuromuscularDystrophin-Associated muscle membrane proteins β-Dystroglycan Sarcoglycans Sarcospan Sarcoglycans 9 Sarcoglycan proteins: Types α-Sarcoglycan (Adhalin) : LGMD R3 (2D) β-Sarcoglycan : LGMD R4 (2E) γ-Sarcoglycan : LGMD R5 (2C) δ-Sarcoglycan : LGMD R6 (2F) ε-Sarcoglycan : Myoclonus-Dystonia syndrome ζ-Sarcoglycan 4 : Structurally related to γ and δ General features Family: Homologous transmembrane proteins with single membrane spanning domain All Sarcoglycans (SG) have Glycosylation Extracellular region Contains cysteine cluster Location N-terminal (Type I): α- & ε-SG C-terminal (Type II): β-, γ-
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Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.