Cell Death/Damage: Mechanisms
MitochondrialIon Channels / Membrane
W
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Overview
From WUSTL NeuromuscularCuproptosis Pyroptosis Necroptosis Autophagy Apoptosis Ferroptosis Necrosis Wallerian Degeneration Consequence Cell death Inflammatory cell death Necrosis Self-degradationCell death when excessive Cell death Cell death Cell death Axon degeneration Molecules/Triggers Copper ↑ Inflammasome activation TNF, TLRs StressOrganelle damage Mitochondrial, orExtrinsic Iron ↑GPX4 inhibitionLipid peroxidation Calcium ↑ NMN/NAD+ ↑TNF-αMLKL Mechanisms Cu binding to lipoylated proteinsMitochondrial Δ Caspase-1 cleavagePore formation RIPK3-MLKLMembrane rupture Lysosomal degradation Caspase activationDNA fragme
Related Conditions
Shared genesExternal Resources
Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.