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Schwann Cell Development

Autosomal DominantLaboratory / DiagnosticsOMIM 107580
W
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Overview

From WUSTL Neuromuscular

Neural crest cells Schwann cell: Types Precursor Immature Mature Myelinating Non-myelinating (Remak) Perisynaptic Autophagic Wallerian Degeneration Denervation Büngner bands Images See: Non-Myelinating Schwann cells Types: Developmental, Mature & Pathology 3 General: Proteins in Schwann cells Present at several stages All stages of development: Sox10 Early stages: α4 integrin; AP2α; NCAD During & after Immature stage: S100β Related to Schwann cell type Myelin clearance: c-jun Repair cell survival: Stat3 Sensor of axon damage & Repair cells: Mitf localization (Controlled by mTorc2) Neural crest

OMIM Entries

OMIM #107580OMIM #114020OMIM #162010OMIM #142445OMIM #164870OMIM #190151OMIM #600543OMIM #602965OMIM #604989OMIM #190198OMIM #605802OMIM #601231OMIM #156845OMIM #102582

Related Conditions

Shared genes
Axon: Caliber
SCCOMPONENTS
CMYO13: Myopathy, Congenital, Bailey-Bloch
III
HEREDITARY ATAXIAS: DOMINANT
IIISPECTRINABC
Semaphorins
III

External Resources

WUSTL Neuromuscular
Washington University Disease Center
OMIM
Online Mendelian Inheritance in Man
PubMed
Biomedical Literature
GeneReviews
NCBI Expert-Authored Reviews
Orphanet
Portal for Rare Diseases
NORD
National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.