Semaphorins

Overview

Protein properties Gene family containing both transmembrane & secreted proteins ~750 amino acids Domains N-terminal signal peptide ~500 amino acid sema domain: Conserved regions ~15 cysteine residues N-linked glycosylation sites Ig (C2) domain: On secreted ± transmembrane proteins C-terminal region Secreted semaphorins: contain region of basic amino acids Transmembrane domain in transmembrane proteins Protein types Transmembrane semaphorins Sema I (fasciclin IV) (G, D & T forms) Peripheral axon guidance cue D-sema II Selective inhibitor of synaptic arborizations Sem B Sem C Secreted semaphori

OMIM Entries

Related Conditions

External Resources