Sensory (± Ataxic) neuropathy with anti-GD1b & other Disialosyl antibodies
Immune/Antibody
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Overview
From WUSTL NeuromuscularNosology Chronic Ataxic Neuropathy with Disialosyl Antibodies (CANDA) CANOMAD Epidemiology Male (75%) > Female Clinical (IgM vs GD1b) Onset Age: 30 to 76 years; Mean 55 years Evolution: Acute, Subacute or Chronic Sensory loss (100%) Distribution Distal Symmetric Legs & Arms Modalities: Large & Small fiber Ataxia Paresthesias Tendon reflexes: Absent Strength Normal in 50% Weakness (50%): Mild; Distal Gait Ataxic (Sensory) + Romberg Tandem relatively spared Cranial nerves Ophthalmoplegia (50% to 90%) Trigeminal (50%): Perioral paresthesias Facial (25%) Bulbar weakness (66%) Course Usual: Slowly
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Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.