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Oculopharyngeal Muscular Dystrophy (OPMD)

Autosomal RecessiveAutosomal DominantMitochondrialVariableMuscular DystrophyOMIM 602279
W
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Overview

From WUSTL Neuromuscular

● Other locus HNRNPA2B1 Differential diagnosis Epidemiology OPMD is common in French-Canadians (1:1,000) Bukhara Jews in Israel (1:600) OPMD is caused by two distinct founder GCG9 mutations in these 2 populations New Mexico Hispanics: GCG9 mutation Louisiana Cajun: GCA containing repeats Japan: GCA containing repeats Netherlands European prevalence: 1 in 100,000 Recessive OPMD: 1 in 10,000 in Quebec; Rare elsewhere (GCN)11 allele: 0.05% frequency in the Thai population. Genetics Common mutations Expansions of GCG trinucleotide repeat in exon 1 Meiotically stable Generational effects: Usually s

OMIM Entries

OMIM #602279OMIM #186000OMIM #142989OMIM #119600OMIM #600211OMIM #603073OMIM #140000OMIM #142959OMIM #110100OMIM #605597

Related Conditions

Shared genes
ANTIBODIES IN CONNECTIVE TISSUE DISORDERS
ASSOCIATEDANTIBODIESPL-12
Inflammatory & Immune Myopathies (IIM): Acquired
RNAVAMPINCLUSION
Myotonic Dystrophy 1 (DM1)
ATPASERNAHT

External Resources

WUSTL Neuromuscular
Washington University Disease Center
OMIM
Online Mendelian Inheritance in Man
PubMed
Biomedical Literature
GeneReviews
NCBI Expert-Authored Reviews
Orphanet
Portal for Rare Diseases
NORD
National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.