ANTIBODIES IN CONNECTIVE TISSUE DISORDERS
Laboratory / Diagnostics
W
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Overview
From WUSTL NeuromuscularAntibody types Cytoplasmic Nuclear Nucleolar Phospholipid Myositis-associated tRNA synthetase Juvenile Other Myositis overlap MYOSITIS-ASSOCIATED ANTIBODIES: General 8 Specificity High for inflammatory myopathies Muscle pathology types: IMPP & Other Sensitivity: 1% to 35% Antibody class: IgG MSA target antigen features Not tissue specific Usually enzyme protein, not tRNA Exception is anti-PL-12 with tRNAAla & enzyme targets Often expressed in regenerating muscle fibers Cleaved by granzyme B Anti-Aminoacyl t-RNA synthetase antibodies 11 Associated clinical features Interstitial lung disease: Mo
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Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.