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Nuclei: Muscle Fibers

MitochondrialSystemic/MultisystemOMIM 604517
W
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Overview

From WUSTL Neuromuscular

Myonuclei Number in skeletal muscle Normal: ~100 per mm of length Age: May decline with loss of muscle Other multinucleated cells: Cardiomyocytes; Cytotrophoblasts; Osteoclasts Position Peripheral (Adjacent to sarcolemma): Adult muscle fibers Internal (Separated from sarcolemma): Immature muscle fibers Disorders Centronuclear myopathies Myotonic Dystrophy: 1; 2 Shape Normal: Oval; Elongated parallel to myofibrils Disorders Nemaline (Rod) myopathies 154 General: Pericentrin Normal: Punctate around nucleus Rod myopathies: Diffuse & Increased on nuclear surface ACTA1: Elongated; Irregular shapes

OMIM Entries

OMIM #604517

Related Conditions

Shared genes
FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1A (FSHMD 1A)
DNMT3BLRIF1SMALL
HERPES ZOSTER (Varicella)
VZVDNAC6
Oculopharyngodistal Myopathies (OPDM)
AS1DISEASEDNA
Vocal Cord & Pharyngeal Weakness (MPD2; VCPDM; ALS21; MSP5)
DNA

External Resources

WUSTL Neuromuscular
Washington University Disease Center
OMIM
Online Mendelian Inheritance in Man
PubMed
Biomedical Literature
GeneReviews
NCBI Expert-Authored Reviews
Orphanet
Portal for Rare Diseases
NORD
National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.