Acute Flaccid Myelitis, EV-D68 (Motor neuronopathy; AFM)
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Overview
From WUSTL NeuromuscularCase definition Timing: After 8/1/2104 Patient age: ≤ 21 years Onset: Acute Weakness: Focal limb MRI: Spinal gray matter lesion EV-D68 Virus Family: Picornaviridae AFM patients: Clade B1 enterovirus D68 EV-D68 virus is retrogradely trensported in motor neuron axons Epidemiology AFM cases: 104 patients in 34 states; Fall 2015 Japanese epidemic AFM association: Cases coincided with national outbreak Severe respiratory disease among children Caused by enterovirus D68 (EV-D68) EV-D68 respiratory tract association with AFM 20% to 64% of AFM cases tested positive for EV-D68 Males > Females Clinical
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Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.