Vasculitis & Autoantibodies
Other NeuromuscularOMIM 177020
W
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Overview
From WUSTL NeuromuscularAnti-Neutrophil Cytoplasmic Antibody (ANCA): General 2 Epidemiology: More frequent with silica dust exposure Methodology Initial testing by immunocytochemistry Confirmation by Western blot: Binding to specific antigen Antibody type Diagnostic purposes: IgG Other described: IgA; IgM ANCA effects Bind to: Neutrophils & Endothelial cells; Azurophilic granules Promote degranulation of neutrophils & monocytes: Facilitates endothelial damage Endothelial activation: Neutrophil adherence is enhanced Release of cytotoxic superoxide and serine proteases Clinical associations Neuropathy Onset: Paresthesi
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Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.