TRANSIENT RECEPTOR POTENTIAL (TRP) ION CHANNELS

MitochondrialAutosomal DominantIon Channels / MembraneOMIM 604775

mother/chan.html#TRANSIENT RECEPTOR POTENTIAL (TRP) ION CHANNELS

Overview

From WUSTL Neuromuscular

General Features Structure Subunits: Contain 6 membrane spanning domains Similarity Voltage gated K+ (Kv) Cyclic nucleotide gated (HCN & CNG) Polycystic kidney disease proteins Form tetramers Pore lined by transmembrane domains 5 & 6 Location: Plasma membrane Functions Cation channel, Non-selective Actions Shift membrane potential to 0 mV Depolarization from resting membrane potentials Allow Ca++ influx in non-excitable cells Some are temperature sensitive Sensations TRPA1: Noxious cold receptor TRPM8: Innocuous cold sensor TRPV1: Noxious heat TRPV4: Pain Other pain related: TRPM2, TRPV3, TRPC

OMIM Entries

OMIM #604775 OMIM #602343 OMIM #602345 OMIM #603651 OMIM #603652 OMIM #603965 OMIM #602076 OMIM #606676 OMIM #607066 OMIM #605427 OMIM #609677 OMIM #601844 OMIM #600442 OMIM #606409 OMIM #156530 OMIM #113500 OMIM #184252 OMIM #168400 OMIM #184095 OMIM #606835 OMIM #606679 OMIM #606680 OMIM #603576 OMIM #603749 OMIM #608961 OMIM #620224 OMIM #620253 OMIM #606936 OMIM #604559 OMIM #618531 OMIM #604600 OMIM #607009 OMIM #602014 OMIM #605692 OMIM #606678 OMIM #601313 OMIM #173910 OMIM #605248 OMIM #252650 OMIM #607399 OMIM #607400

External Resources

WUSTL Neuromuscular

Washington University Disease Center

OMIM

Online Mendelian Inheritance in Man

PubMed

Biomedical Literature

GeneReviews

NCBI Expert-Authored Reviews

Orphanet

Portal for Rare Diseases

NORD

National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.