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THICK FILAMENTS

Ion Channels / Membrane
W
View full entry on WUSTL Neuromuscular
mother/myosin.htm#THICK FILAMENTS

Overview

From WUSTL Neuromuscular

A-bandH-zoneM-lineMyosin Myosins: General Molecular motors Interact with actin filaments: Utilize energy from ATP hydrolysis to generate mechanical force Force generation: Associated with movement of myosin heads to tilt toward each other 3 Degradation Mediated by ubiquitin-proteasome pathway (UPP) Associated E3 ligases ubiquitylating MHC 11 MuRF1: β/slow Cardiac; MHC-IIa Skeletal muscle; MBP C; Myosin light 1 & 2; α-actin UBR2: MYH2B; MYH2X Myosin composition Hexamer: Two trimers Heavy chains: Homodimer Each heavy chain binds 2 light chains Essential light chain (ELC) Regulatory light chain (

Related Conditions

Shared genes
Distal infantile spinal muscular atrophy with diaphragm paralysis (HMNR1; DSMA1; SMARD1; HMN 6)
CMT2SIGHMBP2CMT2

External Resources

WUSTL Neuromuscular
Washington University Disease Center
PubMed
Biomedical Literature
GeneReviews
NCBI Expert-Authored Reviews
Orphanet
Portal for Rare Diseases
NORD
National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.