POEMS Syndrome
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Overview
From WUSTL NeuromuscularGeneral Laboratory Nosology Polyneuropathy Pathology Systemic Edema Endocrine Organomegaly Treatment From M. Al-Lozi POEMS: Skin Thick, Dry Clubbing of fingers From M. Al-Lozi POEMS: Edema POEMS Major diagnostic criteria: 3 needed Mandatory (2) Polyneuropathy Plasma cell proliferative disorder, Monoclonal (λ >> κ) Other (1) Vascular endothelial growth factor (VEGF): High Sclerotic bone lesions Castleman�s disease Minor diagnostic criteria: 1 needed Organomegaly Spleen, Liver; Lymph nodes Extravascular volume ↑ Edema, Pleural effusion, Ascites Endocrinopathy Adrenal, Thyroid, Pituitary, Gonadal
OMIM Entries
External Resources
Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.