Paraneoplastic Sensory Neuronopathy with Anti-Hu Antibodies

Overview

Clinical Features Epidemiology Female: 80% (US study); 15% (European study) White: 98% Age of onset: Mean 60's; Range 39 to 83 Tobacco smoking: > 95% Onset Painful paresthesias & dysesthesias Asymmetric; Distal or Proximal No tumor at initial workup: 50% Sensory loss (95%) All modalities involved Proprioceptive loss: Prominent Ataxia: Sensory Pseudoathetosis Distribution Proximal & Distal Asymmetric (35%) or Symmetric Upper limb only (25%) Lower limb only (45%) Discomfort Pain (80%) Paresthesias Motor Normal (75%) Sensory-motor involvement (25%): May be subclinical Weakness: Proximal or Distal

OMIM Entries

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