Neuropathy: CMT Genes & Drugs
Autosomal DominantAutosomal RecessiveNeuropathy (Hereditary)
W
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Overview
From WUSTL NeuromuscularVincristine: May cause exacerbation of CMT1A: PMP-22 EGR2: Neuropathy in previously asymptomatic patient MORC2: CMT2Z Paclitaxel Polymorphisms associated with neuropathy Periaxin (PRX) ARHGEF10 TRPV4 Experimental data: Inhibition prevents paclitaxel-induced neurotoxicity 142 Isoniazid (INH): May exacebate CMT2A Ethambutol: May exacebate CMT2A Thiopental anesthesia CMT1A: PMP-22 Sensitive to low doses (Lower induction dose needed) Especially with severe motor & sensory involvement HMSN types: Comparison of clinical features 36 Disorder Gene Locus Usual onset Early or distinctsymptoms TendonRefl
Related Conditions
Shared genesAxon: Transport
NUDELJNKSYNAPTIC
Distal infantile spinal muscular atrophy with diaphragm paralysis (HMNR1; DSMA1; SMARD1; HMN 6)
CMT2SIGHMBP2CMT2
EGR2 mutations: CMT 1D & Other phenotypes
CMT2
HEREDITARY MOTOR SENSORY NEUROPATHIES (HMSN; CMT)
DIFCMT1ATP6
Nuclear Protein Disorders: Envelope & Matrix
CMT2
OVERVIEW
CMT2HMN
Recessive, Axonal CMT
CMT2ACMT2BCMT2
Scapular winging
CMT2AC4CAUSES
External Resources
Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.