Fibroblast Growth Factors

Autosomal DominantMitochondrialLaboratory / DiagnosticsOMIM 134920

lab/trophic.htm#Fibroblast Growth Factors

Overview

From WUSTL Neuromuscular

Family of many related 150 to 268 amino acid proteins Control normal growth and differentiation of Mesenchymal, epithelial & neuroectodermal cells Several groups: Basic & acidic originally isolated from brain tissue Basic FGF-2 Identified by proliferation-enhancing activities on murine fibroblasts (3T3 cells). Acidic FGF-1 Identified by proliferation-enhancing activity for myoblasts. Others: int-2 (FGF-3); FGF-5; FGF-6; K-FGF; Keratinocyte growth factor (FGF-7) Other properties Variably secreted Secreted: FGF-3, 4, 5, 6, 7, 8 Not secreted: FGF-1; FGF-2; FGF-9; FHFs Heparin binding of FGFs is s

OMIM Entries

OMIM #134920 OMIM #131220 OMIM #164950 OMIM #610706 OMIM #164980 OMIM #621260 OMIM #165190 OMIM #190330 OMIM #134921 OMIM #148180 OMIM #600483 OMIM #612702 OMIM #600921 OMIM #612961 OMIM #601513 OMIM #617166 OMIM #300070 OMIM #301058 OMIM #601514 OMIM #601515 OMIM #602115 OMIM #180920 OMIM #103420 OMIM #603724 OMIM #603725 OMIM #603726 OMIM #603891 OMIM #605558 OMIM #168600 OMIM #609436 OMIM #605831 OMIM #605380 OMIM #193100 OMIM #211900 OMIM #605830

External Resources

WUSTL Neuromuscular

Washington University Disease Center

OMIM

Online Mendelian Inheritance in Man

PubMed

Biomedical Literature

GeneReviews

NCBI Expert-Authored Reviews

Orphanet

Portal for Rare Diseases

NORD

National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.