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Ferroptosis

Ion Channels / Membrane
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Overview

From WUSTL Neuromuscular

General features Cell death Non-apoptotic Regulated Iron Dependent Accumulation (Free Fe++) Caused by Redox imbalance Inhibition of: GPX4; Cystine/glutamate transporter (Xc) system Lipids: Leads to Excessive Reactive oxygen species (ROS) Peroxidation Mitochondria Regulate ferroptosis Pathology Size: Small Outer membrane: Damaged Cristae: Reduced or Absent Pathways Genes involved GPX4, ACSL4, NRF2, TfR1, FTH1, LPCAT3, SLC7A11, SLC39A14, NCOA4, FSP1, COX2, ACSL4, P53, HSPB1 Associated pathway: Xc-GSH-GPX4 Subunits: SLC7A11; SLC3A2 Glutathione synthesis Inducer: Erastin interaction with VDAC2/3 D

External Resources

WUSTL Neuromuscular
Washington University Disease Center
PubMed
Biomedical Literature
GeneReviews
NCBI Expert-Authored Reviews
Orphanet
Portal for Rare Diseases
NORD
National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.