CHANNEL TYPES: General

Ion Channels / Membrane

mother/chan.html#CHANNEL TYPES: General 9

Overview

From WUSTL Neuromuscular

Extracellular ligand-gated channels: Nicotinoid 5 Homologous polypeptide subunits Subunits have 4 membrane spanning regions Ligands: Neurotransmitters Specific receptors Nicotinic AChR GABAA & GABAC Glycine 5-HT3 Glutamate activated anionic channels Types: NMDA; AMPA; Kainate 4 Homologous subunits Intracellular ligand-gated channels Ligands: cAMP, cGMP, Ca++, G-proteins, Phosphorylation Voltage-gated channels 4 domains Na+ & Ca+ channels: In single polypeptide chain K+ channel: Tetramer of 4 similar subunits Each domain has 6 membrane spanning regions S4 sequence Contains + charged amino acids

Related Conditions

Shared genes

ION CHANNELS, TRANSMITTERS, RECEPTORS & DISEASE

HT3GLUTAMATE

External Resources

WUSTL Neuromuscular

Washington University Disease Center

PubMed

Biomedical Literature

GeneReviews

NCBI Expert-Authored Reviews

Orphanet

Portal for Rare Diseases

NORD

National Organization for Rare Disorders

Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.