Celiac Disease (Gluten-sensitive enteropathy)
Other Neuromuscular
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Overview
From WUSTL NeuromuscularGeneral: Allergic reaction to gluten in cereals T-cell-mediated immune response against ingested gluten in genetically predisposed people Antigenic target: Transglutaminase Causes injury to mucosa in small bowel Genetic factors 10 percent prevalence of celiac disease among first-degree relatives HLA types HLA-DQ2: 90% to 95% express ((α)1501,(β)102) heterodimer HLA-DQ8: Found in most other celiac disease patients Concordance rates Monozygotic twins: 70% HLA-identical sibs: 30% Predisposition in Finnish families: Linked to chromosome 15q11-q13 Epidemiology Female > Male Frequency Most common in
External Resources
Data sourced from the Washington University Neuromuscular Disease Center. For clinical use, always refer to primary sources.